| Club: | Lecce |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Saverio Sticchi Damiani |
| Mgrtitle: | Head coach |
| Manager: | Marco Baroni |
| Stadium: | Stadio Via del Mare |
| League: | Serie B |
| League Result: | 1st (promoted) |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Massimo Coda (20) |
| Season Topscorer: | Massimo Coda (22) |
| Largest Win: | Lecce 4–0 Parma |
| Largest Loss: | Cremonese 3–0 Lecce |
| Pattern La1: | _lecce2122h |
| Leftarm1: | DCDC38 |
| Pattern B1: | _lecce2122h |
| Body1: | DCDC38 |
| Pattern Ra1: | _lecce2122h |
| Rightarm1: | DCDC38 |
| Pattern Sh1: | _lecce2122h |
| Shorts1: | 09246C |
| Pattern So1: | _lecce2122h |
| Socks1: | D31F4C |
| Pattern B2: | _lecce2122a |
| Body2: | FFFFFF |
| Pattern La2: | _lecce2122a |
| Leftarm2: | FFFFFF |
| Pattern Ra2: | _lecce2122a |
| Rightarm2: | FFFFFF |
| Pattern Sh2: | _lecce2122a |
| Shorts2: | FFFFFF |
| Pattern So2: | _lecce2122a |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was U.S. Lecce's second consecutive season in second division of the Italian football league, the Serie B, and the 95th as a football club.
See main article: 2021–22 Serie B.
The league fixtures were announced on 24 July 2021.[1]
See main article: 2021–22 Coppa Italia.