| Club: | Cremonese |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Paolo Rossi |
| Owner: | Giovanni Arvedi |
| Mgrtitle: | Head coach |
| Manager: | Fabio Pecchia |
| Stadium: | Stadio Giovanni Zini |
| League: | Serie B |
| League Result: | 2nd (promoted) |
| Cup1: | Coppa Italia |
| Cup1 Result: | First round |
| League Topscorer: | Cristian Buonaiuto Daniel Ciofani (8 each) |
| Season Topscorer: | Cristian Buonaiuto Daniel Ciofani (8 each) |
| Pattern B1: | _cremonese1920h |
| Body1: | a1a1a1 |
| Pattern La1: | _cremonese1920h |
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| Pattern Ra1: | _cremonese1920h |
| Rightarm1: | a1a1a1 |
| Pattern Sh1: | _cremonese1920h |
| Shorts1: | FF0000 |
| Pattern So1: | _cremonese1920h |
| Socks1: | FF0000 |
| Pattern B2: | _cremonese2021a |
| Body2: | FFFFFF |
| Pattern La2: | _cremonese2021a |
| Leftarm2: | FFFFFF |
| Pattern Ra2: | _cremonese2021a |
| Rightarm2: | FFFFFF |
| Pattern Sh2: | _cremonese2021a |
| Shorts2: | FFFFFF |
| Pattern So2: | _cremonese2021a |
| Socks2: | FFFFFF |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was U.S. Cremonese's second consecutive season in second division of the Italian football league, the Serie B, and the 119th as a football club.
See main article: 2021–22 Serie B.
The league fixtures were announced on 24 July 2021.[1]
See main article: 2021–22 Coppa Italia.