| Club: | Sampdoria |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Massimo Ferrero |
| Mgrtitle: | Head coach |
| Manager: | Roberto D'Aversa (until 17 January) Marco Giampaolo (from 18 January) |
| Stadium: | Stadio Luigi Ferraris |
| League: | Serie A |
| League Result: | 15th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Francesco Caputo (11) |
| Season Topscorer: | Francesco Caputo (11) |
| Pattern B1: | _samp2122h |
| Body1: | 2345c0 |
| Pattern La1: | _samp2122h |
| Leftarm1: | 2234a4 |
| Pattern Ra1: | _samp2122h |
| Rightarm1: | 2345c0 |
| Pattern Sh1: | _samp2122h |
| Shorts1: | FFFFFF |
| Socks1: | FFFFFF |
| Pattern B2: | _samp2122a |
| Body2: | FFFFFF |
| Pattern La2: | _samp2122a |
| Leftarm2: | FFFFFF |
| Pattern Ra2: | _samp2122a |
| Rightarm2: | FFFFFF |
| Pattern Sh2: | _samp2122a |
| Shorts2: | FFFFFF |
| Pattern So2: | _samp2122a |
| Socks2: | ff |
| Pattern B3: | _samp2122t |
| Body3: | e63314 |
| Pattern La3: | _samp2122t |
| Leftarm3: | e63314 |
| Pattern Ra3: | _samp2122t |
| Rightarm3: | e63314 |
| Pattern Sh3: | _samp2122t |
| Shorts3: | e63314 |
| Pattern So3: | _samp2122t |
| Socks3: | e63314 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 76th season in the existence of U.C. Sampdoria and the club's 10th consecutive season in the top flight of Italian football. In addition to the domestic league, Sampdoria participated in this season's edition of the Coppa Italia.
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[2]
See main article: 2021–22 Coppa Italia.
|-! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers|-! colspan=14 style=background:#dcdcdc; text-align:center| Defenders|-! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders|-! colspan=14 style=background:#dcdcdc; text-align:center| Forwards|-! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season|-