| Competition: | TFF First League |
| Season: | 2021–22 |
| Winners: | MKE Ankaragücü |
| Promoted: | MKE Ankaragücü Ümraniyespor İstanbulspor |
| Relegated: | Kocaelispor Bursaspor Menemenspor Balıkesirspor |
| League Topscorer: | Ahmet Sagat (17 goals) |
| Biggest Home Win: | (19 December 2021) |
| Biggest Away Win: | (22 January 2022) |
| Highest Scoring: | (11 September 2021) (17 October 2021) |
| Matches: | 342 |
| Total Goals: | 901 |
| Longest Wins: | (6 matches) |
| Longest Unbeaten: | (11 matches) |
| Longest Winless: | (15 matches) |
| Longest Losses: | (8 matches) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Updated: | 21 May 2022 |
The 2021–22 TFF First League was the 21st season since the league was established in 2001 and 59th season of the second-level football league of Turkey since its establishment in 1963–64.
The table lists the positions of teams after each week of matches. In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.
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First leg
Second leg
| Rank | Player | Team | Goals |
|---|---|---|---|
| 1 | Ahmet Sagat | Menemenspor | 17 |
| 2 |  İbrahim Yılmaz | İstanbulspor | 16 |
| Emeka Friday Eze | Ankara Keçiörengücü | ||
| 4 | Umut Bulut | Eyüpspor | 14 |
| 5 | Ömer Şişmanoğlu | Denizlispor | 13 |
 Sandro Lima | Gençlerbirliği | ||
| 7 | Yasin Öztekin | Samsunspor | 12 |
| Kabongo Kasongo | Boluspor | ||
| 9 | Ahmet İlhan Özek | Altınordu | 11 |
| Pa Dibba | Eyüpspor | ||
 Philippe Kény | Bandırmaspor | ||