| Mode: | Women's basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Stephen F. Austin Ladyjacks |
| Conference: | Western Athletic Conference |
| Short Conf: | WAC |
| Record: | 28–5 |
| Conf Record: | 17–1 |
| Hc Year: | 7th |
| Asst Coach1: | Leonard Bishop |
| Asst Coach2: | Erin Mill-Reid |
| Asst Coach3: | Chamissa Anderson |
| Champion: | WAC regular season champions |
| Bowl Result: | first round |
The 2021–22 Stephen F. Austin Ladyjacks basketball team represented Stephen F. Austin University during the 2021–22 NCAA Division I women's basketball season. The Ladyjacks, led by seventh-year head coach Mark Kellogg, played their home games at the William R. Johnson Coliseum in Nacogdoches, Texas as members of the Western Athletic Conference (WAC).
This season is the Ladyjacks' first as members of the Western Athletic Conference. Stephen F. Austin is one of four schools, all from Texas, that left the Southland Conference in July 2021 to join the WAC.
|-!colspan=9 style=| Non-conference regular season|-!colspan=9 style=| WAC season|-!colspan=9 style=|WAC tournament|-!colspan=9 style=|NCAA tournament