| Mode: | Basketball |
| Sex: | none |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Southern Miss Lady Eagles |
| Conference: | Conference USA |
| Short Conf: | CUSA |
| Division: | West Division |
| Record: | 18–12 |
| Conf Record: | 9–8 |
| Head Coach: | Joye Lee-McNelis |
| Hc Year: | 18th |
| Asst Coach1: | Jack Trosper |
| Asst Coach2: | Patosha Jeffery |
| Asst Coach3: | Kaitlynn Pacholke |
The 2021–22 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2021–22 NCAA Division I women's basketball season. The team was led by 18th-year head coach Joye Lee-McNelis, and played their home games at the Reed Green Coliseum in Hattiesburg, Mississippi as a member of Conference USA (C-USA).[1]
On March 31, 2022, Southern Miss announced that this will be the last season for the team in the C-USA and will join the Sun Belt Conference on July 1, 2022.[2]
|-!colspan=12 style=|Exhibition|-!colspan=12 style=|Non-conference regular season|-!colspan=12 style=|CUSA regular season|-!colspan=12 style=| C-USA tournament