| Mode: | Basketball |
| Sex: | none |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Southern Miss Golden Eagles |
| Conference: | Conference USA |
| Short Conf: | C-USA |
| Division: | West Division |
| Record: | 7–26 |
| Conf Record: | 1–17 |
| Hc Year: | 3rd |
| Asst Coach1: | Kyle Roane |
The 2021–22 Southern Miss Golden Eagles basketball team represented the University of Southern Mississippi during the 2021–22 NCAA Division I men's basketball season. The team was led by third-year head coach Jay Ladner, and played their home games at Reed Green Coliseum in Hattiesburg, Mississippi as members of Conference USA (C-USA).
On October 28, 2021, Southern Miss announced that this would be the last season for the team in the C-USA and they would become a member of the Sun Belt Conference on July 1, 2022.
In a season limited due to the ongoing COVID-19 pandemic, the Golden Eagles finished the 2020–21 season 8–17, 4–13 in C-USA play last place in West Division. They lost in the first round of the C-USA tournament to Rice.
| Name | Number | Pos. | Height | Weight | Year | Hometown | Reason for departure | |
|---|---|---|---|---|---|---|---|---|
| Justin Johnson | 2 | G/F | 6'6" | 185 | Junior | Transferred to Texas–Rio Grande Valley | ||
| LaDavius Draine | 11 | G | 6'4" | 210 | Senior | Graduate transferred to Tulsa | ||
| Javarzia Belton | 20 | F | 6'10" | 275 | Freshman | Left the team for personal reasons | ||
| Jay Malone | 21 | G | 6'0" | 167 | RS Junior | Left the team for personal reasons | ||
| Artur Konotsuk | 34 | F | 6'8" | 213 | Sophomore | Left the team for personal reasons |
| Name | Number | Pos. | Height | Weight | Year | Hometown | Previous School | |
|---|---|---|---|---|---|---|---|---|
| Walyn Napper | 1 | G | 6'0" | 170 | Sophomore | Dodge City CC | ||
| Isaih Moore | 11 | F | 6'10" | 205 | Junior | St. John's | ||
| Mo Arnold | 12 | G | 6'2" | 180 | Sophomore | Jacksonville | ||
| Tate Ryder | 25 | G | 6'0" | 170 | Sophomore | East Central CC |
|-!colspan=9 style=|Exhibition|-!colspan=12 style=|Regular season|-!colspan=12 style=| C-USA tournamentSource[1]