| Mode: | Basketball |
| Sex: | none |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Southeastern Louisiana Lions |
| Conference: | Southland Conference |
| Short Conf: | Southland |
| Record: | 19–15 |
| Conf Record: | 10–4 |
| Head Coach: | David Kiefer |
| Hc Year: | 3rd |
| Asst Coach1: | Mark Lieberman |
| Asst Coach2: | Riley Conroy |
| Asst Coach3: | Roger Woods |
| Stadium: | University Center (Capacity: 7,500) |
| Champion: | Southland Basketball Tip-Off champions |
| Bowl: | The Basketball Classic |
| Bowl Result: | First round |
The 2021–22 Southeastern Louisiana Lions basketball team represented Southeastern Louisiana University during the 2021–22 NCAA Division I men's basketball season. The Lions were led by third-year head coach David Kiefer, and played their home games at the University Center in Hammond, Louisiana as members of the Southland Conference.
In a season limited due to the ongoing COVID-19 pandemic, the Lions finished the 2020–21 season 8–18, 5–10 in Southland play, to finish in ninth place. They defeated McNeese State in the first round of the Southland tournament before losing to New Orleans.
|-!colspan=9 style=| Non-conference regular season|-!colspan=9 style=| Southland Conference season|-!colspan=9 style=| Southland tournament|-!colspan=9 style=| The Basketball ClassicSource[1]