| Pixels: | 200px |
| Competition: | Premier Soccer League |
| Winners: | Mamelodi Sundowns (12th title) |
| Relegated: | Baroka F.C. |
| Continentalcup1: | Champions League |
| Continentalcup2: | Confederation Cup |
| Matches: | 240 |
| Total Goals: | 480 |
| League Topscorer: | Peter Shalulile (23 goals) |
| Highest Scoring: | Cape Town City 4-3 Golden Arrows (23 October 2021) |
| Biggest Home Win: | Mamelodi Sundowns 6 - 0 Golden Arrows |
| Biggest Away Win: | Marumo Gallants 0 - 4 Mamelodi Sundowns |
| Longest Wins: | (14 games) Mamelodi Sundowns |
| Longest Unbeaten: | (17 games) Mamelodi Sundowns |
| Longest Winless: | (9 games) Marumo Gallants |
| Longest Losses: | (6 games) TS Galaxy |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Country: | (16 teams) |
| Dates: | 20 August 2021 – 30 May 2022 |
| Season: | 2021–22 |
The 2021–22 South African Premier Division season from 20 August 2021 to 30 May 2022 (known as the DSTV Premiership for sponsorship reasons) was the 26th season of the Premier Soccer League since its establishment in 1996. Mamelodi Sundowns were the four-time defending champions. This season's winner will qualify for the 2022–23 CAF Champions League along with the second placed team. The 3rd placed team and Nedbank Cup winners qualify for the 2022–23 CAF Confederation Cup.
The following teams have changed division since the 2020–21 season.
Relegated from 2020–21 South African Premier Division
Promoted to 2021–22 South African Premier Division
See main article: List of Premier Soccer League Hat-tricks.
| Player | For | Against | Result | Date | |
|---|---|---|---|---|---|
| Mamelodi Sundowns | Swallows | 42 (A) | 6 April 2022 | ||
| Mamelodi Sundowns | Golden Arrows | 60 (H) | 12 April 2022 |