| Year: | 2021–22 |
| Team: | Siena Saints |
| Sport: | basketball |
| Conference: | Metro Atlantic Athletic Conference |
| Short Conf: | MAAC |
| Record: | 15–14 |
| Conf Record: | 12–8 |
| Head Coach: | Carmen Maciariello |
| Hc Year: | 3rd |
| Asst Coach1: | Bobby Castagna |
| Asst Coach2: | Greg Fahey |
| Asst Coach3: | Marcus King |
| Stadium: | MVP Arena |
The 2021–22 Siena Saints men's basketball team represented Siena College in the 2021–22 NCAA Division I men's basketball season. The Saints, led by third-year head coach Carmen Maciariello, played their home games at MVP Arena in Albany, New York as members of the Metro Atlantic Athletic Conference.
The Saints finished the 2020–21 season 12–5, 12–4 in MAAC play to finish as MAAC regular season co-champions alongside Monmouth. As the #1 seed in the MAAC tournament, they were upset by #9 seed Iona in the quarterfinals.[1]
|-!colspan=12 style=""| Exhibition|-!colspan=12 style=""| Regular season|-!colspan=9 style=""| MAAC tournamentSource[2]