| Competition: | Serie A (women) |
| Season: | 2021–22 |
| Winners: | Juventus |
| Relegated: | Verona Lazio Napoli |
| Continentalcup1: | Women's Champions League |
| Continentalcup1 Qualifiers: | Juventus Roma |
| League Topscorer: | Daniela Sabatino (15) |
| Biggest Home Win: | Roma 8–0 Sampdoria (7 May 2022) |
| Biggest Away Win: | Lazio 1–8 Milan (11 September 2021) |
| Highest Scoring: | Lazio 1–8 Milan (11 September 2021) |
| Longest Wins: | Juventus (12 matches) |
| Longest Unbeaten: | Juventus (14 matches) |
| Longest Winless: | Verona (17 matches) |
| Longest Losses: | Lazio (9 matches) |
| Matches: | 132 |
| Total Goals: | 430 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Serie A (women) was the 55th season of the women's football top-level league in Italy. It began on 28 August 2021.[1]
| Team | Home city | Stadium | 2020–21 season | |
|---|---|---|---|---|
| Empoli | Empoli | Centro sportivo Monteboro | 6th in Serie A | |
| Fiorentina | Florence | Stadio Gino Bozzi | 4th in Serie A | |
| Hellas Verona | Verona | Sinergy Stadium | 9th in Serie A | |
| Internazionale | Milan | Stadio Felice Chinetti | 8th in Serie A | |
| Juventus | Turin | Juventus Center (Vinovo) | Champions | |
| Lazio | Rome | Centro sportivo di Formello | 1st in Serie B | |
| Milan | Milan | Centro Sportivo Vismara | 2nd in Serie A | |
| Napoli | Naples | Stadio Caduti di Brema | 10th in Serie A | |
| Pomigliano | Pomigliano | Stadio Ugo Gobbato | 2nd in Serie B | |
| Roma | Rome | Stadio Tre Fontane | 5th in Serie A | |
| Sampdoria | Genoa | Centro sportivo Gloriano Mugnaini | Florentia's license | |
| Sassuolo | Sassuolo | Stadio Enzo Ricci | 3rd in Serie A |
Teams play each other twice for a total of 22 games. Three teams get relegated, because the next season will see a change of format and only ten teams in the league. This is an effort to professionalize the league.[2]
| Rank | Player | Club | Goals[3] |
|---|---|---|---|
| 1 |  Daniela Sabatino | Fiorentina | 15 |
| 2 | Lana Clelland | Sassuolo | 11 |
| 3 | Valentina Giacinti | Fiorentina | 10 |
 Lindsey Thomas | Milan | ||
| Tatiana Bonetti | Internazionale | ||
 Paloma Lázaro | Roma |
| Rank | Player | Club | Assists | |
|---|---|---|---|---|
| 1 |  Yoreli Rincón | Sampdoria | 9 | |
| 2 | Manuela Giugliano | Roma | 8 | |
| 3 | Linda Tucceri Cimini | Milan | 7 |