| Mode: | Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Saint Mary's Gaels |
| Conference: | West Coast Conference |
| Short Conf: | WCC |
| Record: | 26–8 |
| Conf Record: | 12–3 |
| Coachrank: | 20 |
| Aprank: | 18 |
| Hc Year: | 21st |
| Asst Coach1: | Marcus Schroeder |
| Asst Coach2: | Justin Joyner |
| Stadium: | University Credit Union Pavilion (Capacity: 3,500) |
| Bowl Result: | second round |
The 2021–22 Saint Mary's Gaels men's basketball team represented Saint Mary's College of California during the 2021–22 NCAA Division I men's basketball season. The team were led by head coach Randy Bennett in his 21st season at Saint Mary's. The Gaels played their home games at the University Credit Union Pavilion in Moraga, California, as members of the West Coast Conference (WCC). They finished the season 26–8, 12–3 in WCC play to finish in second place. As the No. 2 seed in WCC tournament, they defeated Santa Clara in the semifinals, before losing to Gonzaga in the Championship. They received an at-large bid to the NCAA tournament as the No. 5 seed in the East Region, where they defeated Indiana in the first round before losing to UCLA in the second round.
The Gaels finished the 2020–21 season 14–10, 4–6 in WCC play to finish in seventh place. They defeated Loyola Marymount before losing to Gonzaga in the semifinals of the WCC tournament. They received an at-large bid to the NIT where they lost to Western Kentucky in the first round.
There were no Saint Mary's players that departed or transferred.
|-!colspan=9 style=| Non-conference regular season|-!colspan=9 style=| WCC regular season|-!colspan=9 style=| WCC tournament|-!colspan=9 style=| NCAA tournamentSource[1]
See also: 2021–22 NCAA Division I men's basketball rankings. *AP does not release post-NCAA Tournament rankings.
^Coaches did not release a Week 1 poll.