| Club: | SC Paderborn 07 |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Elmar Volkmann |
| Mgrtitle: | Head coach |
| Manager: | Lukas Kwasniok |
| Stadium: | Benteler-Arena |
| League: | 2. Bundesliga |
| League Result: | 7th |
| Cup1: | DFB-Pokal |
| Cup1 Result: | First round |
| Pattern La1: | _paderborn2122h |
| Pattern B1: | _paderborn2122h |
| Pattern Ra1: | _paderborn2122h |
| Pattern Sh1: | _paderborn2122h |
| Pattern So1: | _blacktop |
| Socks1: | 0033FF |
| Pattern La2: | _paderborn2021a |
| Pattern B2: | _paderborn2021a |
| Pattern Ra2: | _paderborn2021a |
| Pattern Sh2: | _paderborn2021a |
| Pattern So2: | _blacktop |
| Socks2: | FFFF00 |
| Pattern La3: | _paderborn2122t |
| Pattern B3: | _paderborn2122t |
| Pattern Ra3: | _paderborn2122t |
| Pattern Sh3: | _paderborn2122t |
| Pattern So3: | _paderborn2122tl |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 115th season in the existence of SC Paderborn 07 and the club's second consecutive season in the second division of German football. In addition to the domestic league, SC Paderborn participated in this season's edition of the DFB-Pokal.
See main article: 2021–22 2. Bundesliga.
The league fixtures were announced on 25 June 2021.[1]
See main article: 2021–22 DFB-Pokal.