| Club: | Lazio |
| Season: | 2021–22 |
| Owner: | Claudio Lotito |
| Chrtitle: | Chairman |
| Chairman: | Claudio Lotito |
| Mgrtitle: | Head coach |
| Manager: | Maurizio Sarri |
| Stadium: | Stadio Olimpico |
| League: | Serie A |
| League Result: | 5th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Quarter-finals |
| Cup2: | UEFA Europa League |
| Cup2 Result: | Knockout round play-offs |
| League Topscorer: | Ciro Immobile (27) |
| Season Topscorer: | Ciro Immobile (32) |
| Largest Win: | Lazio 6–1 Spezia |
| Largest Loss: | Bologna 3–0 Lazio Hellas Verona 4–1 Lazio |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 122nd season in the existence of S.S. Lazio and the club's 34th consecutive season in the top flight of Italian football. In addition to the domestic league, Lazio participated in this season's editions of the Coppa Italia and the UEFA Europa League.
| Date | Player | Moving from | Fee | Notes | Source | |||
|---|---|---|---|---|---|---|---|---|
 Dimitrije Kamenović | Čukarički | €2,500,000 | [1] | |||||
 Felipe Anderson | West Ham United | €3,000,000 | [2] | |||||
 Elseid Hysaj | Napoli | Free | [3] | |||||
 Luka Romero | Mallorca | €200,000 | [4] | |||||
 Pedro | Roma | Undisclosed | [5] | |||||
| Toma Bašić | Bordeaux | €6,860,000 | [6] | |||||
 Mattia Zaccagni | Hellas Verona | Loan | Loan until the end of the season | |||||
 Jovane Cabral | Sporting CP | Loan (€1,000,000) | Loan until the end of the season with option to buy for €8,000,000 | [7] |
| Date | Player | Moving to | Fee | Notes | Source | |||
|---|---|---|---|---|---|---|---|---|
 Senad Lulić | Free agent | Free | [8] | |||||
| Marco Parolo | Free agent | Free | [9] | |||||
| Mateo Musacchio | Free agent | Free | ||||||
| Damiano Franco | Reggina | Free | ||||||
 Szymon Czyż | Warta Poznań | Free | ||||||
| Andreas Pereira | Manchester United | End of loan | Loan until the end of the season | [10] | ||||
| Wesley Hoedt | Southampton | End of loan | Loan until the end of the season | |||||
| Gabriel Pereira | Monaco | End of loan | Loan until the end of the season | |||||
| GK | Marco Alia | Monterosi | Loan | Loan until the end of the season | ||||
| Sergio Kalaj | Carrarese | Free | [11] | |||||
| DF | Mattia Novella | Monopoli | Loan | Loan until the end of the season | ||||
| DF | Nicolò Armini | Piacenza | Loan | Loan until the end of the season | ||||
| Simone Palombi | Alessandria | Free | [12] | |||||
| Joaquín Correa | Inter | Loan (€6,000,000) | Loan until the end of the season with option to buy for €23,600,000 | |||||
 Felipe Caicedo | Genoa | €2,000,000 | ||||||
| DF | Tiago Casasola | Frosinone | Loan | Loan until the end of the season | ||||
| MF | Fabio Maistro | Ascoli | Loan | Loan until the end of season | ||||
| DF | Angelo Ndrecka | Teramo | Loan | Loan until the end of season | ||||
| FW | Emanuele Cicerelli | Frosinone | Loan | Loan until the end of the season | ||||
| Gonzalo Escalante | Alavés | Loan | Loan until the end of the season | [13] | ||||
 Denis Vavro | Copenhagen | Loan | Loan until the end of the season with option to buy | [14] | ||||
| DF | Tiago Casasola | Cremonese | Loan | Loan until the end of the season | ||||
| Bobby Adekanye | Crotone | Loan | Loan until the end of the season | |||||
| Jony | Sporting Gijón | Loan | Loan until the end of the season 2022-2023 | |||||
| Cristiano Lombardi | Reggina | Loan | Loan until the end of the season | |||||
| Vedat Muriqi | Mallorca | Loan (€1,000,000) | Loan until the end of the season with option to buy for €12,000,000 | [15] | ||||
| FW | André Anderson | São Paulo | Loan | Loan until the end of the season 2022-2023 |
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[16]
See main article: 2021–22 Coppa Italia.
See main article: 2021–22 UEFA Europa League.
The draw for the group stage was held on 27 August 2021.[17]
See main article: 2021–22 UEFA Europa League knockout phase.
The knockout round play-offs draw was held on 13 December 2021.[18]
|-! colspan=14 style="background:#B2FFFF; text-align:center"| Goalkeepers|-! colspan=14 style="background:#B2FFFF; text-align:center"| Defenders|-! colspan=14 style="background:#B2FFFF; text-align:center"| Midfielders|-! colspan=14 style="background:#B2FFFF; text-align:center"| Forwards|-! colspan=14 style="background:#B2FFFF; text-align:center"| Players transferred out during the season
| Rank | Player | Serie A | Coppa Italia | Europa League | Total | |
|---|---|---|---|---|---|---|
| 1 | Ciro Immobile | 27 | 1 | 4 | 32 | |
| 2 | Pedro | 7 | 0 | 1 | 8 | |
| 3 | Sergej Milinković-Savić | 7 | 0 | 0 | 7 | |
| 4 | Felipe Anderson | 3 | 0 | 1 | 4 | |
| 5 | Luis Alberto | 3 | 0 | 0 | 3 | |
| align=center colspan=2 | Own goals | 0 | 0 | 0 | 0 | |
| Total | 46 | 1 | 7 | 54 | ||