| Club: | Napoli |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Aurelio De Laurentiis |
| Mgrtitle: | Head coach |
| Manager: | Luciano Spalletti |
| Stadium: | Stadio Diego Armando Maradona |
| League: | Serie A |
| League Result: | 3rd |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| Cup2: | UEFA Europa League |
| Cup2 Result: | Knockout round play-offs |
| League Topscorer: | Victor Osimhen (14) |
| Season Topscorer: | Victor Osimhen (18) |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 76th season in the existence of SSC Napoli and the club's 15th consecutive season in the top flight of Italian football. In addition to the domestic league, Napoli participated in this season's editions of the Coppa Italia and the UEFA Europa League.
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| Date | Player | Moving from | Fee | Notes | Source | |||
|---|---|---|---|---|---|---|---|---|
 Matteo Politano | Internazionale | €25M | Loan deal made permanent | [1] | ||||
 Kévin Malcuit | Fiorentina | N/A | Loan return | |||||
| Adam Ounas | Crotone | N/A | Loan return | |||||
| Alessandro Zanoli | Legnago | N/A | Loan return | |||||
 Juan Jesus | Roma | Free | End of contract | [2] | ||||
| Amin Younes | Eintracht Frankfurt | N/A | Loan terminated early | [3] |
| Date | Player | Moving from | Fee | Notes | Source | |||
|---|---|---|---|---|---|---|---|---|
 André-Frank Zambo Anguissa | Fulham | N/A | One year loan with option to buy | [4] | ||||
| Axel Tuanzebe | Manchester United | N/A | Six month loan | [5] |
| Date | Player | Moving to | Fee | Notes | Source | |||
|---|---|---|---|---|---|---|---|---|
| Tiémoué Bakayoko | Chelsea | N/A | End of loan | |||||
 Elseid Hysaj | Lazio | Free | End of contract | [6] | ||||
 Nikola Maksimović | Genoa | Free | End of contract | [7] | ||||
| Kostas Manolas | Olympiacos | €2.5M | [8] | |||||
| Amin Younes | Al-Ettifaq | Free | [9] |
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[11]
See main article: 2021–22 Coppa Italia.
See main article: 2021–22 UEFA Europa League.
The draw for the group stage was held on 27 August 2021.[12]
See main article: 2021–22 UEFA Europa League knockout phase.
The knockout round play-offs draw was held on 13 December 2021.[13]
Last updated on 22 May 2022|-! colspan=14 style="background:#5DAFE3; color:#FFFFFF; text-align:center"| Goalkeepers|-! colspan=14 style="background:#5DAFE3; color:#FFFFFF; text-align:center"| Defenders|-! colspan=14 style="background:#5DAFE3; color:#FFFFFF; text-align:center"| Midfielders|-! colspan=14 style="background:#5DAFE3; color:#FFFFFF; text-align:center"| Forwards|-! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season
| width=15 | width=15 | width=15 | width=15 | width=145 | Player | width=120 | Serie A | width=120 | Coppa Italia | width=120 | Europa League | width=120 | Total | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 9 | FW |  | Victor Osimhen | 14 | 0 | 4 | 18 | |||||||||
| 2 | 14 | FW |  | Dries Mertens | 11 | 1 | 1 | 13 | |||||||||
| 24 | FW | | Lorenzo Insigne | 11 | 0 | 2 | 13 | ||||||||||
| 4 | 20 | MF |  | Piotr Zieliński | 6 | 0 | 2 | 8 | |||||||||
| 5 | 7 | MF |  | Eljif Elmas | 3 | 0 | 4 | 7 | |||||||||
| 8 | MF |  | Fabián Ruiz | 7 | 0 | 0 | 7 | ||||||||||
| 7 | 11 | FW |  | Hirving Lozano | 5 | 0 | 1 | 6 | |||||||||
| 8 | 21 | FW | | Matteo Politano | 3 | 0 | 2 | 5 | |||||||||
| 9 | 13 | DF | Amir Rrahmani | 4 | 0 | 0 | 4 | ||||||||||
| 37 | FW | | Andrea Petagna | 3 | 1 | 0 | 4 | ||||||||||
| 11 | 26 | DF |  | Kalidou Koulibaly | 3 | 0 | 0 | 3 | |||||||||
| 12 | 33 | FW |  | Adam Ounas | 0 | 0 | 2 | 2 | |||||||||
| 13 | 4 | MF |  | Diego Demme | 1 | 0 | 0 | 1 | |||||||||
| 5 | DF | | Juan Jesus | 1 | 0 | 0 | 1 | ||||||||||
| 22 | DF | | Giovanni Di Lorenzo | 1 | 0 | 0 | 1 | ||||||||||
| 68 | MF |  | Stanislav Lobotka | 1 | 0 | 0 | 1 | ||||||||||
| Totals | 74 | 2 | 18 | 94 | |||||||||||||