| Mode: | Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Radford Highlanders |
| Conference: | Big South Conference |
| Short Conf: | Big South |
| Record: | 11–18 |
| Conf Record: | 7–9 |
| Hc Year: | 1st |
| Asst Coach1: | Shane Nichols |
| Asst Coach2: | Timothy Peete |
| Asst Coach3: | James Haring |
The 2021–22 Radford Highlanders men's basketball team represented Radford University in the 2021–22 NCAA Division I men's basketball season. The Highlanders, led by first-year head coach Darris Nichols, played their home games at the Dedmon Center in Radford, Virginia, as members of the Big South Conference.
The Highlanders finished the 2020–21 season 15–12, 12–6 in Big South play to finish in second place. They lost to Campbell in the semifinals of the Big South tournament.
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