| Club: | Charleroi |
| Season: | 2021–22 |
| Owner: | Fabien Debecq |
| Chrtitle: | Managing director |
| Chairman: | Mehdi Bayat |
| Mgrtitle: | Head coach |
| Manager: | Edward Still |
| Stadium: | Stade du Pays de Charleroi |
| League: | First Division A |
| League Result: | 6th |
| Cup1: | Belgian Cup |
| Cup1 Result: | Sixth round |
| League Topscorer: | Vakoun Issouf Bayo (11) |
| Season Topscorer: | Vakoun Issouf Bayo (11) |
| Largest Win: | Charleroi 5–0 Cercle Brugge |
| Largest Loss: | Union Saint-Gilloise 4–0 Charleroi Anderlecht 4–0 Charleroi |
| Pattern La1: | _charleroi2122h |
| Pattern B1: | _charleroi2122h |
| Pattern Ra1: | _charleroi2122h |
| Pattern Sh1: | _cercle2021h |
| Leftarm1: | 000000 |
| Body1: | 000000 |
| Rightarm1: | 000000 |
| Shorts1: | 000000 |
| Socks1: | 000000 |
| Pattern La2: | _charleroi2122a |
| Pattern B2: | _charleroi2122a |
| Pattern Ra2: | _charleroi2122a |
| Pattern Sh2: | _cercle2021a |
| Leftarm2: | FFFFFF |
| Body2: | FFFFFF |
| Rightarm2: | FFFFFF |
| Shorts2: | FFFFFF |
| Socks2: | FFFFFF |
| Pattern La3: | _charleroi2021a |
| Pattern B3: | _charleroi2021a |
| Pattern Ra3: | _charleroi2021a |
| Leftarm3: | FE2E9A |
| Body3: | FE2E9A |
| Rightarm3: | FE2E9A |
| Shorts3: | FE2E9A |
| Socks3: | FE2E9A |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 118th season in the existence of Royal Charleroi S.C. and the club's 10th consecutive season in the top flight of Belgian football. In addition to the domestic league, R. Charleroi S.C. participated in this season's edition of the Belgian Cup.
| No. | Pos | Player | Loaned from | Fee | Date | On loan until | Source | |||
|---|---|---|---|---|---|---|---|---|---|---|
 Vakoun Issouf Bayo | ||||||||||
See main article: 2021–22 Belgian First Division A.
The league fixtures were announced on 8 June 2021.[1]
See main article: 2021–22 Belgian Cup.