| Mode: | Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Purdue Fort Wayne Mastodons |
| Conference: | Horizon League |
| Short Conf: | Horizon |
| Record: | 21–12 |
| Conf Record: | 15–6 |
| Hc Year: | 8th |
| Asst Coach1: | Ryan Sims |
| Ac1 Year: | 12th |
| Asst Coach2: | Adam Blaylock |
| Ac2 Year: | 4th |
| Asst Coach3: | Mike Wolf |
| Ac3 Year: | 3rd |
| Asst Coach4: | Pat Lepper |
| Ac4 Year: | 1st |
| Champion: | Horizon League co-regular season champions |
| Bowl Result: | First Round |
The 2021–22 Purdue Fort Wayne Mastodons men's basketball team represented Purdue University Fort Wayne in the 2021–22 NCAA Division I men's basketball season. The Mastodons, led by eighth-year head coach Jon Coffman, played their home games at the Hilliard Gates Sports Center in Fort Wayne, Indiana, as members of the Horizon League. They finished the regular season 21–11, 15–6 to earn a share of the regular season championship. As the No. 2 seed in the Horizon League tournament, they defeated UIC in the quarterfinals before losing to Northern Kentucky in the semifinals. They received a bid to the College Basketball Invitational, where they lost to top seed Drake in the first round.
In a season limited due to the ongoing COVID-19 pandemic, the Mastodons finished the 2020–21 season 8–15, 6–14 in Horizon League play to finish in 11th place. In the Horizon League tournament, they defeated Green Bay in the first round before losing to Cleveland State in the quarterfinals.
| Name | Number | Pos. | Height | Weight | Year | Hometown | Reason for departure | |
|---|---|---|---|---|---|---|---|---|
| Justice Prentice | 2 | G | 6'1" | 175 | Freshman | Transferred to Western Texas College | ||
| Matt Havey | 10 | G | 6'1" | 185 | RS Sophomore | Left team | ||
| Dylan Carl | 11 | F | 6'11" | 240 | RS Senior | Graduated | ||
| Bryce Waterman | 22 | G | 6'6" | 205 | Sophomore | Transferred to College of Staten Island | ||
| DeMierre Black | 24 | G | 6'0" | 185 | Senior | Graduated | ||
| Demetric Horton | 25 | G | 6'5" | 200 | Junior | Transferred to North Carolina A&T |
| Name | Number | Pos. | Height | Weight | Year | Hometown | Previous School | |
|---|---|---|---|---|---|---|---|---|
| Damian Chong Qui | 2 | G | 5'8" | 155 | Senior | Mount St. Mary's | ||
| Quinton Morton-Robertson | 11 | G | 5'8" | 165 | Junior | Radford | ||
| RJ Ogom | 23 | F | 6'6" | 230 | RS Freshman | College of Charleston |
|-!colspan=12 style=| Exhibition|-!colspan=12 style=|Regular season|-!colspan=9 style=| Horizon League tournament|-!colspan=9 style=| CBI|-Source[1] [2]