| Club: | Portimonense S.C. |
| Season: | 2021–22 |
| Chrtitle: | Chairman |
| Chairman: | Fernando Rocha |
| Mgrtitle: | Manager |
| Manager: | Paulo Sérgio |
| Stadium: | Estádio Municipal |
| League: | Primeira Liga |
| League Result: | 11th |
| Cup1: | Taça de Portugal |
| Cup1 Result: | Quarter-finals |
| Cup2: | Taça da Liga |
| Cup2 Result: | Second round |
| Pattern La1: | _portimonense1617h |
| Pattern B1: | _portimonense1920h |
| Pattern Ra1: | _portimonense1617h |
| Leftarm1: | ffffff |
| Body1: | 000000 |
| Rightarm1: | ffffff |
| Shorts1: | 000000 |
| Socks1: | ffffff |
| Pattern La2: | _portimonense1920a |
| Pattern B2: | _portimonense1920a |
| Pattern Ra2: | _portimonense1920a |
| Pattern Sh2: | _portimonense1920a |
| Leftarm2: | FFE303 |
| Body2: | FFE303 |
| Rightarm2: | FFE303 |
| Shorts2: | ffffff |
| Socks2: | FF6600 |
| Pattern La3: | _portimonense2122a |
| Pattern B3: | _portimonense2122a |
| Pattern Ra3: | _portimonense2122a |
| Leftarm3: | FFFFFF |
| Body3: | FFFFFF |
| Rightarm3: | FFFFFF |
| Shorts3: | FFFFFF |
| Socks3: | 000000 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season is the 72nd season in the existence of Portimonense S.C. and the club's third consecutive season in the top flight of Portuguese football. In addition to the domestic league, Portimonense S.C. participated in this season's editions of the Taça de Portugal and the Taça da Liga.
See main article: 2021–22 Primeira Liga.
See main article: 2021–22 Taça de Portugal.
See main article: 2021–22 Taça da Liga.