| Club: | Pisa |
| Season: | 2021–22 |
| Chairman: | Giuseppe Corrado |
| Owner: | Alexander Knaster |
| Manager: | Luca D'Angelo |
| Stadium: | Arena Garibaldi |
| League: | Serie B |
| League Result: | 3rd |
| Cup1: | Play-offs |
| Cup1 Result: | Runners-up |
| Cup2: | Coppa Italia |
| Cup2 Result: | First round |
| Largest Loss: | Benevento 5–1 Pisa |
| Pattern La1: | _pisa2122h |
| Pattern B1: | _pisa2122h |
| Pattern Ra1: | _pisa2122h |
| Pattern Sh1: | _adidasblue |
| Pattern So1: | _color_3_stripes_blue |
| Leftarm1: | 000000 |
| Body1: | 0000FF |
| Rightarm1: | 000000 |
| Shorts1: | 000000 |
| Socks1: | 000000 |
| Pattern La2: | _pisa2122t |
| Pattern B2: | _pisa2122t |
| Pattern Ra2: | _pisa2122t |
| Pattern Sh2: | _adidasblack |
| Pattern So2: | _color_3_stripes_black |
| Leftarm2: | EED488 |
| Body2: | EED488 |
| Rightarm2: | EED488 |
| Shorts2: | EED488 |
| Socks2: | EED488 |
| Pattern La3: | _pisa2122a |
| Pattern B3: | _pisa2122a |
| Pattern Ra3: | _pisa2122a |
| Pattern Sh3: | _adidaswhite |
| Pattern So3: | _color_3_stripes_white |
| Leftarm3: | 006030 |
| Body3: | 006030 |
| Rightarm3: | 006030 |
| Shorts3: | 006030 |
| Socks3: | 006030 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was Pisa S.C.'s third consecutive season in second division of the Italian football league, the Serie B, and the 113th as a football club.
See main article: 2021–22 Serie B.
The league fixtures were announced on 24 July 2021.[1]
See main article: 2021–22 Coppa Italia.