| Club: | Paris Saint-Germain Féminine |
| Season: | 2021–22 |
| Owner: | Qatar Sports Investments |
| Chrtitle: | President |
| Chairman: | Nasser Al-Khelaifi |
| Mgrtitle: | Head coach |
| Manager: | Didier Ollé-Nicolle |
| Stadium: | Stade Jean-Bouin Stade Municipal Georges Lefèvre Parc des Princes |
| League: | Division 1 Féminine |
| League Result: | 2nd |
| Cup1: | Coupe de France Féminine |
| Cup1 Result: | Winners |
| Cup2: | Trophée des Championnes |
| Cup2 Result: | Cancelled |
| Cup3: | UEFA Women's Champions League |
| Cup3 Result: | Semi-finals |
| League Topscorer: | Marie-Antoinette Katoto (18) |
| Season Topscorer: | Marie-Antoinette Katoto (32) |
| Highest Attendance: | 43,255 vs Lyon, UEFA Women's Champions League, 30 April 2022 |
| Lowest Attendance: | 75 vs Bordeaux Division 1 Féminine, 12 December 2021 |
| Largest Win: | 8–0 vs Yzeure, Coupe de France Féminine, 15 May 2022 |
| Largest Loss: | 1-6 vs Lyon, Division 1 Féminine, 14 November 2021 |
| Pattern Name1: | Home |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 51st season in the existence of Paris Saint-Germain Féminine and the club's 35th season in the top flight of French football. In addition to the domestic league, they participated in the Coupe de France Féminine and the UEFA Women's Champions League.
Ahead of the 2021–22 season, it was announced that Olivier Echouafni would leave the club after three seasons in charge with former Nice men's manager Didier Ollé-Nicolle replacing him as manager.
See main article: 2021–22 Division 1 Féminine.
See main article: Trophée des Championnes.
PSG qualified for the Trophée des Championnes by winning the 2020–21 Division 1 Féminine, but the match was cancelled due to the ongoing impacts of the COVID-19 pandemic in France.[1]
See main article: 2021–22 UEFA Women's Champions League.
The group stage draw was held on 13 September 2021.[2]
See main article: 2021–22 UEFA Women's Champions League knockout phase. The draw for the knockout phase was held on 20 December 2021.[3]
Paris Saint-Germain won 4–3 on aggregate.
Lyon won 5–3 on aggregate.