| Club: | Oud-Heverlee Leuven |
| Season: | 2021–22 |
| Ownertitle: | Owner |
| Owner: | King Power International Group |
| Chrtitle: | Chairman |
| Chairman: | Aiyawatt Srivaddhanaprabha |
| Mgrtitle: | Manager |
| Manager: | Marc Brys |
| Stadium: | Den Dreef |
| League: | Belgian First Division A |
| League Result: | 11th |
| Cup1: | Belgian Cup |
| Cup1 Result: | Quarter-finals |
| League Topscorer: | Sory Kaba (10) |
| Season Topscorer: | Sory Kaba (12) |
| Pattern La1: | _ohl2122h |
| Pattern B1: | _ohl2122h |
| Pattern Ra1: | _ohl2122h |
| Pattern Sh1: | _ohl2122h |
| Pattern So1: | _color_3_stripes_green |
| Leftarm1: | FFFFFF |
| Rightarm1: | FFFFFF |
| Shorts1: | FFFFFF |
| Socks1: | FFFFFF |
| Pattern B2: | _ohl2122a |
| Pattern Sh2: | _ohl2122a |
| Pattern So2: | _ohl2122a |
| Leftarm2: | 000050 |
| Body2: | 000050 |
| Rightarm2: | 000050 |
| Shorts2: | 000050 |
| Socks2: | 000050 |
| Pattern B3: | _ohl1920a |
| Pattern Sh3: | _ohl1920a |
| Pattern So3: | _ohl1920a |
| Leftarm3: | 8888AA |
| Body3: | FFFFFF |
| Rightarm3: | 8888AA |
| Shorts3: | FFFFFF |
| Socks3: | 8888AA |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 20th season in the existence of Oud-Heverlee Leuven and its second consecutive season in the top flight of Belgian football. In addition to the domestic league, Oud-Heverlee Leuven participated in this season's edition of the Belgian Cup.
| No. | Nationality | Name | Position | Joined First Team | Previous Club | Left First Team | |
|---|---|---|---|---|---|---|---|
| Goalkeepers | |||||||
| 13 | Rúnar Alex Rúnarssonℒ | GK | 31 August 2021 | Arsenal | (30 June 2022) | ||
| 38 | Oregan Ravet¥ | GK | Summer 2019 | Youth Squad | – | ||
| 90 | / | Rafael Romo | GK | 19 August 2020 | Silkeborg | – | |
| Defenders | |||||||
| 3 | Sofian Chakla | CB | 27 August 2021 | Villarreal | – | ||
| 5 | / | Pierre-Yves Ngawa | RB | 11 August 2019 | Perugia | – | |
| 6 | Sébastien Dewaestℒ | CB | 20 July 2021 | Genk | (30 June 2022) | ||
| 15 | / | Dylan Ouédraogo | CB | 28 August 2019 | Apollon Limassol | – | |
| 18 | Barnabás Bese | RB | 20 August 2020 | Le Havre | 3 January 2022 | ||
| 24 | Casper de Norre | LB/RB | 5 October 2020 | Genk | – | ||
| 25 | Louis Patris¥ | CB | Summer 2019 | Youth Squad | – | ||
| 28 | Toon Raemaekers¥ | CB | Summer 2019 | Youth Squad | – | ||
| 29 | Scotty Sadzoute | LB | 7 July 2021 | Lille | 31 January 2022 | ||
| 35 | Cenk Özkacarℒ | LB | 6 July 2021 | Lyon | (30 June 2022) | ||
| 46 | Milan Taildeman¥ | LB | Summer 2021 | Youth Squad | – | ||
| Midfielders | |||||||
| 4 | Kristiyan Malinov | DM / CM | 20 August 2020 | CSKA Sofia | – | ||
| 10 | Xavier Mercier | CM | 16 June 2019 | Cercle Brugge | – | ||
| 11 | Musa Al-Taamari | RW | 5 October 2020 | APOEL | – | ||
| 14 | Thibault Vlietinckℒ | RW | 12 August 2020 | Club Brugge | (30 June 2022) | ||
| 20 | / | Isaac Asante¥ | AM | Winter 2019–20 | Youth Squad | – | |
| 21 | Alexis De Sartℒ | CM | 22 August 2021 | Antwerp | (30 June 2022) | ||
| 27 | Mandela Keita¥ | CM | Winter 2020–21 | Youth Squad | – | ||
| 33 | Mathieu Maertens | CM / AM | 12 July 2017 | Cercle Brugge | – | ||
| 42 | Jo Gilis¥ | AM | Summer 2018 | Youth Squad | – | ||
| Forwards | |||||||
| 7 | / | Yannick Aguemon | CF / LW / RW | 28 June 2017 |  Union SG | – | |
| 8 | Siebe Schrijvers | CF / AM / RW | 15 January 2021 | Club Brugge | – | ||
| 9 | Thomas Henry | CF | 17 January 2019 | Tubize | 24 August 2021 | ||
| 9 | Sory Kabaℒ | CF | 31 August 2021 | Midtjylland | (30 June 2022) | ||
| 17 | Mykola Kukharevychℒ | CF | 1 September 2021 | Troyes | (30 June 2022) | ||
| 19 | Levan Shengelia | RW | 11 August 2021 | Konyaspor | – | ||
| 32 | Daan Vekemans¥ | CF | Summer 2018 | Youth Squad | – | ||
| 39 | Arthur Allemeersch¥ | CF | Summer 2019 | Youth Squad | – | ||
| 77 | Jesse Sekidikaℒ | RW | 27 August 2021 | Galatasaray | 31 January 2022 | ||
| 99 | Kaveh Rezaei | CF | 4 January 2021 | Club Brugge | – |
The following players were listed as part of Oud-Heveree Leuven's first team squad during the 2021–22 season, but never appeared on the match sheet
| No. | Nationality | Name | Position | Joined First Team | Previous Club | Left First Team | Note | |
|---|---|---|---|---|---|---|---|---|
| 1 | Kawin Thamsatchanan | GK | 10 January 2018 | Muangthong United | 4 January 2022 | Not on match sheet in first half of season, then loaned to Port until 30 June 2022 | ||
| 20 | Cedrik Gbo | DM | 11 March 2022 | ES Tunis | (30 June 2022) | |||
| 24 | Tristan Borges | CM / LW / RW | 22 January 2020 | Forge FC | – | Was on loan to Forge FC until 30 November 2021, then placed at reserves. Again loaned out to Forge FC from 31 January 2022 until the end of the season. |
See main article: 2021–22 Belgian First Division A.
The league fixtures were announced on 8 June 2021.[1]
See main article: 2021–22 Belgian Cup.