| Competition: | Oman Professional League |
| Season: | 2021–22 |
| Winners: | Al-Seeb (2nd title) |
| Relegated: | Muscat, Nizwa, Saham. |
| Continentalcup1: | AFC Champions League |
| Continentalcup2: | AFC Cup |
| Continentalcup2 Qualifiers: | Al-Seeb |
| Matches: | 182 |
| Total Goals: | 399 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Continentalcup3: | GCC Champions League |
The 2021–22 Oman Professional League is the 46th edition of the Oman Professional League, the top football league in Oman. The season started on 16 October 2021.
The same teams from the cancelled season will continue. The clubs are:
| Team | Location | Stadium | Capacity | |
|---|---|---|---|---|
| Dhofar Club | Salalah | Al-Saada Stadium | 8,000 | |
| Al-Seeb Club | Seeb | Al-Seeb Stadium | 14,000 | |
| Sohar SC | Sohar | Sohar Club Stadium | 3,350 | |
| Saham Club | Sohar | Sohar Regional Sports Complex | 19,000 | |
| Oman Club | Muscat | Sultan Qaboos Sports Complex | 34,000 | |
| Nizwa Club | Nizwa | Nizwa Sports Complex | 15,000 | |
| Al-Nasr SC | Salalah | Al-Saada Stadium | 8,000 | |
| Bahla Club | ||||
| Al Rustaq Club | Rustaq | Rustaq Sports Complex | 17,000 | |
| Suwaiq Club | Seeb | Al-Seeb Stadium | 14,000 | |
| Al-Nahda Club | Al-Buraimi | Al-Buraimi Sports Stadium | 17,000 | |
| Al-Ittihad Club | Salalah | Al-Saada Stadium | 8,000 | |
| Muscat Club | Muscat | Sultan Qaboos Sports Complex | 34,000 | |
| Al-Musannah SC | Seeb | Al-Seeb Stadium | 14,000 |