| Mode: | Women's basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Ole Miss Rebels |
| Conference: | Southeastern Conference |
| Short Conf: | SEC |
| Record: | 23–9 |
| Conf Record: | 10–6 |
| Hc Year: | 4th |
| Asst Coach1: | Chris Ayers |
| Asst Coach3: | Shay Robinson |
| Bowl Result: | first round |
The 2021–22 Ole Miss Rebels women's basketball team represented the University of Mississippi during the 2021–22 NCAA Division I women's basketball season. The Rebels, led by fourth-year head coach Yolett McPhee-McCuin, played their home games at The Sandy and John Black Pavilion at Ole Miss and competed as members of the Southeastern Conference (SEC).
The Rebels finished the season 15–12 (4–10 SEC) and received an at-large bid to the Women's National Invitation Tournament, where they lost to Rice in the championship game.
| Name | Number | Pos. | Height | Year | Hometown | Notes | |
|---|---|---|---|---|---|---|---|
| Sarah Dumitrescu | 1 | G | 6'0" | RS Freshman | Bucharest, Romania | Transferred to Cal Poly | |
| Valerie Nesbitt | 4 | G | 5'8" | Senior | Nassau, Bahamas | Signed with CB Islas Canarias | |
| Taylor Smith | 21 | G | 5'8" | Junior | Marietta, GA | Transferred to Xavier | |
| [1] [2] [3] | |||||||
| Name | Number | Pos. | Height | Year | Hometown | Previous school | |
|---|---|---|---|---|---|---|---|
| Lashonda Monk | 1 | G | 5'6" | Graduate Student | East Carolina | ||
| Destiny Salary | 10 | G | 6'0" | Sophomore | Tennessee | ||
| Angel Baker | 15 | G | 5'8" | Senior | Wright State | ||
| [4] | |||||||
|-!colspan=9 style=| Non-conference regular season|-!colspan=9 style=| SEC regular season|-!colspan=9 style=| SEC Tournament|-!colspan=9 style=| NCAA tournament