| Club: | OFI Crete F.C. |
| Season: | 2021–22 |
| Ownertitle: | Owner |
| Owner: | Michael Bousis |
| Chrtitle: | President |
| Chairman: | Michael Bousis |
| Mgrtitle: | Head coach |
| Manager: | Nikos Nioplias |
| Stadium: | Theodoros Vardinogiannis Stadium |
| League: | Super League 1 |
| League Result: | 8th |
| Cup1: | Greek Cup |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Juan Neira (6) |
| Season Topscorer: | Juan Neira (6) |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 OFI Crete F.C. season was the club's 97th season in existence and the fourth consecutive season in the top flight of Greek football. In addition to the domestic league, OFI participated in this season's edition of the Greek Football Cup. The season covered the period from 1 July 2021 to 30 June 2022.
See main article: 2021–22 Super League Greece.
See main article: 2021–22 Greek Football Cup.