| Mode: | Basketball |
| Year: | 2021–22 |
| Team: | North Florida Ospreys |
| Conference: | ASUN Conference |
| Division: | East Division |
| Short Conf: | ASUN |
| Record: | 11–20 |
| Conf Record: | 7–9 |
| Hc Year: | 13th |
| Assoc Coach: | Bobby Kennen |
| Asst Coach1: | Bruce Evans |
| Asst Coach2: | Stephen Perkins |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
The 2021–22 North Florida Ospreys men's basketball team represented the University of North Florida in the 2021–22 NCAA Division I men's basketball season. The Ospreys, led by 13th-year head coach Matthew Driscoll, played their home games at the UNF Arena in Jacksonville, Florida as members of the East Division of the ASUN Conference.
In a season limited due to the ongoing COVID-19 pandemic, the Ospreys finished the 2020–21 season 8–15, 6–6 in ASUN play, to finish in fourth place. In the ASUN tournament, they lost to North Alabama in the quarterfinals.
|-!colspan=12 style=| Regular season |-!colspan=12 style=| ASUN tournament|-|-Source[1]