| Competition: | Nigeria Professional Football League |
| Season: | 2021–22 |
| Continentalcup1: | CAF Champions League |
| Continentalcup2: | CAF Confederation Cup |
| Date: | 17 December 2021 – 22 July 2022 |
| Matches: | 380 |
| Total Goals: | 779 |
| League Topscorer: | Chijioke Akuneto (19 goals) |
| Biggest Home Win: | Plateau United 5–0 Dakkada (16 January 2022) Akwa United 6–1 Nasarawa United (22 April 2022) Rivers United 5–0 MFM (8 May 2022) |
| Biggest Away Win: | Heartland 0–3 Enugu Rangers (21 January 2022) Akwa United 0–3 Enugu Rangers (13 March 2022) |
| Highest Scoring: | Enugu Rangers 5–3 Lobi Stars (19 March 2022) |
| Longest Wins: | Plateau United (5 matches) |
| Longest Unbeaten: | Rivers United (12 matches) |
| Longest Winless: | Heartland & MFM (7 matches) |
| Longest Losses: | Heartland, MFM & Lobi Stars (5 matches) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Updated: | 17 July 2022 |
The 2021–22 Nigeria Professional Football League was the 51st season of Nigeria's top-flight association football league and the 32nd since attaining professionalism. The season started on 17 December 2021 and was concluded on 17 July 2022.[1]
This season saw Shooting Stars returning to the top-flight after a four-year hiatus, likewise Niger Tornadoes who won the National League play-offs. They were also joined by Remo Stars and Gombe United after securing promotion from the second division.[2] Akwa United were the defending champions.
On 25 June 2022, Rivers United won their first league title with 4 matches to spare.[3]
Kano Pillars were relegated for the first time in 20 years[4] .This occurred as a result of the team suffering a six point deduction from the league committee and the club's poor form during the season, they were joined by MFM, Heartland and Katsina United. Remo Stars secured a continental ticket for the first time in the club's history.[5]
Not including interim management.
| Team | Outgoing manager | Manner of departure | Date of departure | Incoming manager | Date of appointment | |
|---|---|---|---|---|---|---|
| Heartland |  Hassan Abdallah | Resignation | 2 February | Erasmus Onuh | 5 February[6] | |
| Akwa United | Kennedy Boboye | Resignation | 13 February[7] | Deji Ayeni | 23 March | |
| Lobi Stars | Eddy Dombraye | Sacked | 14 March | Mohammed Babaganaru | 24 March | |
| Sunshine Stars | Deji Ayeni | Left for Akwa United | 23 March |  Emmanuel Deutsch | 2 April | |
| MFM | Gabriel Olalekan | Sacked | 11 May | Festus Allen | 11 May[8] |
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Rivers United | 19 | |
| 1 | Yusuf Abdulazeez | Gombe United | 16 |
| Victor Mbaoma | Enyimba | ||
| 4 | Odoh Valentine | Abia Warriors | 15 |
| 5 | Ishaq Rafiu | Rivers United | 14 |
| 6 | Andy Okpe | Remo Stars | 13 |
| 7 | Godwin Obaje | Abia Warriors | 12 |
| 8 | Zulkifilu Rabiu | Plateau United | 11 |
| Tochukwu Udeh | Nasarawa United | ||
| 10 | Samad Kadiri | Kwara United | 10 |
| Ossy Martins | Enugu Rangers | ||
| Leonard Ugochukwu | Sunshine Stars |
| Chijioke Akuneto | Rivers United | Akwa United | 4–1 (H) | 20 March 2022[9] | |
| Victor Mbaoma | Enyimba | Kwara United | 3–0 (H) | 12 June 2022[10] | |
| Andy Okpe | Remo Stars | Niger Tornadoes | 3–0 (H) | 17 July 2022 |