| Nedbank Cup | |
| Year: | 2021–22 |
| Other Titles: | ke yona (the one) |
| Country: | South Africa |
| Num Teams: | 32 |
| Defending Champions: | Tshakhuma Tsha Madzivhandila F.C. |
| Continentalcup1: | 2022–23 CAF Confederation Cup |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Nedbank Cup was the 2021–22 edition of South Africa's premier knockout club football (soccer) competition, the Nedbank Cup.
Eight teams from the SAFA Second Division (called the ABC Motsepe League for sponsorship reasons) qualify for the round of 32. One team from each of the nine provinces is selected, with two teams drawn to play each other in a knockout to reduce the number to eight. The nine teams from the provinces were:
Mathaithai and Mikhado were selected to play each other, with Mathaithai winning the playoff.
Eight teams from the National First Division also qualify, with the sixteen teams meeting in a preliminary round.
The last 32 of 2021-22 is made up of 16 teams from the South African Premier Division, 8 teams from the National First Division and 8 from the SAFA Second Division.