| Club: | Lokomotiva |
| Season: | 2021–22 |
| Chrtitle: | Chairman |
| Chairman: | Miroslav Gluhinić |
| Mgrtitle: | Manager |
| Manager: | Silvijo Čabraja |
| Stadium: | Stadion Kranjčevićeva |
| League: | Prva HNL |
| League Result: | 5th |
| Cup1: | Croatian Cup |
| Cup1 Result: | Quarter-finals |
| Pattern La1: | _lokomotivaz2122h |
| Pattern B1: | _lokomotivaz2122h |
| Pattern Ra1: | _lokomotivaz2122h |
| Pattern Sh1: | _lokomotivaz2021h |
| Pattern So1: | _lokomotivaz1920h |
| Leftarm1: | 0000FF |
| Body1: | FFFFFF |
| Rightarm1: | 0000FF |
| Shorts1: | 0000FF |
| Socks1: | 0000FF |
| Pattern La2: | _adidasregista20wrb |
| Pattern B2: | _adidasregista20wrb |
| Pattern Ra2: | _adidasregista20wrb |
| Pattern Sh2: | _lokomotivaz2122a |
| Pattern So2: | _color_3_stripes_blue |
| Leftarm2: | FFFFFF |
| Body2: | FFFFFF |
| Rightarm2: | FFFFFF |
| Shorts2: | FFFFFF |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season is the 108th season in the existence of NK Lokomotiva Zagreb and the club's 13th consecutive season in the top flight of Croatian football. In addition to the domestic league, NK Lokomotiva Zagreb participated in this season's edition of the Croatian Cup.
See main article: 2021–22 Croatian First Football League.
The league fixtures were announced on 8 June 2021.[1]
See main article: 2021–22 Croatian Football Cup.