| Competition: | Moldovan Women Top League |
| Season: | 2021–22 |
| Winners: | Maksimum Cahul |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Agarista Anenii Noi |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Moldovan Women Top League was the 22nd season of the highest women's football league in Moldova. The competition started on 12 September 2021 and ended on 29 May 2022.
| Club | Location | |
|---|---|---|
| Anenii Noi | ||
| Bălți | ||
| Tiraspol | ||
| Cahul | ||
| Nimoreni | ||
| Chișinău |
On 20 October 2021 due to withdrawal of Nistru Cioburciu and Narta Drăsliceni, the executive committee changed the format and clubs will play each other three times instead of twice.
Nistru withdrew without playing a single game, Narta played two games and lost them both with their results annulled.[1]
Teams play each other twice (once home, once away).
Teams play every other team once (either at home or away).
| Rank | Player | Club | Goals[2] | |
|---|---|---|---|---|
| 1 |  Iuliana Colnic | Maksimum | 22 | |
| 2 | Anisia Său | Noroc & Agarista | 9 | |
| 3 | Doina Ciobanu | Maksimum | 7 |