| Mode: | women's basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Mercer Bears |
| Conference: | Southern Conference |
| Short Conf: | SoCon |
| Record: | 23-6 |
| Conf Record: | 13-1 |
| Hc Year: | 12th |
| Asst Coach1: | Ben Wierzba |
| Asst Coach2: | David Lowery |
| Asst Coach3: | Marqu'es Webb |
| Stadium: | Hawkins Arena |
| Champion: | SoCon Regular Season Champions SoCon Tournament Champions |
| Tourney: | NCAA tournament |
| Tourney Result: | first round |
The 2021–22 Mercer Bears women's basketball team represented Mercer University during the 2021–22 NCAA Division I women's basketball season. The Bears, led by twelfth-year head coach Susie Gardner, played their home games at the Hawkins Arena as members of the Southern Conference (SoCon). They finished the season 23–6, 13–1 in the Southern Conference, winning the regular season and tournament championships, and representing SoCon in the 2022 NCAA Division I women's basketball tournament.
[1] |-!colspan=9 style=| Non-conference regular season|-!colspan=9 style=| SoCon regular season|-!colspan=9 style=| SoCon Tournament|-!colspan=9 style=| NCAA Tournament