| Mode: | Women's Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Marshall Thundering Herd |
| Conference: | Conference USA |
| Division: | East |
| Short Conf: | CUSA |
| Record: | 15–13 |
| Conf Record: | 10–8 |
| Head Coach: | Tony Kemper |
| Hc Year: | 5th |
| Asst Coach1: | Janko Popovic |
| Asst Coach2: | Jenna Burdette |
| Asst Coach3: | Lexie Barrier |
| Stadium: | Cam Henderson Center |
The 2021–22 Marshall Thundering Herd women's basketball team represented Marshall University during the 2021–22 NCAA Division I women's basketball season. The Thundering Herd, led by fifth-year head coach Tony Kemper, played their home games at Cam Henderson Center in Huntington, West Virginia as members of the Conference USA. They finished with a record of 15–13, 10–8 in C-USA play to finish in fifth place in the East Division. They lost to Rice in the second round of the C-USA tournament.
|-!colspan=12 style=|Non-conference regular season|-!colspan=12 style=|C-USA regular season|-!colspan=12 style=| C-USA Tournament