| Competition: | Macedonian Second League |
| Season: | 2021–22 |
| Dates: | 25 August 2021 – 14 May 2022 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Macedonian Second Football League was the 30th season of the Macedonian Second Football League, the second division in the Macedonian football league system. The season began on 25 August 2021 and concluded on 14 May 2022.[1]
| Club | City | Stadium | Capacity | |
|---|---|---|---|---|
| Belasica | Strumica | Stadion Mladost | 6,500 | |
| Bratstvo 07 | Žitoše | Smajo Kolasinac | 500 | |
| Radovish | Gradski stadion Radovish | 2,000 | ||
| Kozhuf | Gevgelija | Gradski stadion Gevgelija | 1,400 | |
| Osogovo | Kochani | Stadion Nikola Mantov | 4,350 | |
| Lokomotiva | Gradsko | Stadion Gradsko | 300 | |
| Pehchevo | Pehchevo | Gradski stadion Pehchevo | 1,200 | |
| Pobeda | Prilep | Gradski stadion Goce Delchev | 15,000 | |
| Sasa | Makedonska Kamenica | Gradski stadion M. Kamenica | 5,000 | |
| Sloga 1934 | Vinica | Gradski stadion Vinica | 3,000 |
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Bojan Spirkoski | Pobeda | 20 |
| 2 | Toshe Manov | Osogovo | 17 |
| 3 | Aleksandar Kocev | Belasica | 11 |
| 4 | Ivan Mitrov | Sloga 1934 | 9 |
| Bojan Ivanov | Sloga 1934 | ||
| Club | City | Stadium | Capacity | |
|---|---|---|---|---|
| Besa | Dobri Dol | Global Arena | 4,000 | |
| Gostivar | Gostivar | Gradski stadion Gostivar | 1,000 | |
| Kadino | Kadino | Stadion Kadino | 500 | |
| Korabi | Debar | Gradski stadion Debar | 2,500 | |
| Ohrid | Ohrid | SRC Biljanini Izvori | 3,000 | |
| Sileks | Kratovo | City Stadium Kratovo | 4,000 | |
| Teteks | Tetovo | AMS Sportski Centar Tetovo | 2,000 | |
| Vardar | Skopje | Stadion Zhelezarnica | 3,000 | |
| Veleshta | Veleshta | Stadion Veleshta | ||
| Voska Sport | Ohrid | SRC Biljanini Izvori | 3,000 |
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Izair Emini | Voska Sport | 15 |
| 2 | Filip Petkovski | Vardar | 13 |
| 3 | Gjorgji Tanushev | Sileks | 11 |
| 4 | Antonio Kalanoski | Sileks | 10 |
| 5 | Damjan Masevski | Teteks | 9 |