| Competition: | Macedonian Super League |
| Season: | 2021–22 |
| Dates: | 12 September 2021 – 3 June 2022 |
| Winners: | Vardar 1961 15th title |
| Relegated: | Metalurg |
| Continentalcup1: | Champions League |
| Continentalcup2: | European League |
| Continentalcup2 Qualifiers: | Eurofarm Pelister Butel Skopje Eurofarm Pelister 2 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Macedonian Handball Super League was the 30th season of the Super League, North Macedonia's premier handball league. It ram from 12 September 2021 to 3 June 2022.[1]
Vardar won their fifteenth title.[2]
The following 12 clubs compete in the Super League during the 2021–22 season:
| Team | Location | Arena | Capacity | |
|---|---|---|---|---|
| Butel | Skopje, Butel | Sala Butel | 1,000 | |
| Metalurg | Skopje | Avtokomanda Boris Trajkovski Arena | 2,000 6,500 | |
| Ohrid | Ohrid | Biljanini Izvori Sports Hall | 3,000 | |
| Eurofarm Pelister | Bitola | Boro Čurlevski Sports Hall | 3,700 | |
| Eurofarm Pelister 2 | Bitola | Boro Čurlevski Sports Hall | 3,700 | |
| Prilep | Prilep | Riste Risteski- Ricko | 200 | |
| Prolet 62 | Skopje, Prolet | Makedonsko Sonce Arena | 1,200 | |
| Radoviš | Radoviš | SRC 25ti Maj | 2,500 | |
| Skopje 2020 | Skopje | |||
| Struga | Struga | Sala Struga | 1,200 | |
| Tikveš 2014 | Tikveš | Jasmin Sports Hall | 2,500 | |
| Vardar 1961 | Skopje | Jane Sandanski Arena | 6,000 |
The 11th-placed teams of the Macedonian Super League faces the 4th-placed team of the Group B in Macedonian First League.
|}Skopje 2020 won the 28–27 int these match, and therefore both clubs remain in their respective leagues.[3]