| Club: | Macclesfield |
| Season: | 2021–22 |
| Ownertitle: | Owner |
| Owner: | Robert Smethurst |
| Manager: | Danny Whitaker |
| Stadium: | Leasing.com Stadium |
| League: | NWCFL Premier Division |
| League Result: | 1st (promoted) |
| Cup1: | FA Cup |
| Cup1 Result: | Preliminary Round |
| Cup2: | FA Vase |
| Cup2 Result: | First Qualifying Round |
| Cup3: | NWCFL Challenge Cup |
| Cup3 Result: | Quarter-final |
| League Topscorer: | Tom Clare & Neil Danns (21) |
| Season Topscorer: | Tom Clare (23) |
| Highest Attendance: | 4,720 vs. AFC Liverpool, NWCFL Premier Division, (2 April 2022) |
| Average Attendance: | 3,390 |
| Largest Win: | 6–0 vs. Vauxhall Motors (A) (22 February 2022) 6–0 vs. Avro (H) (19 March 2022) |
| Nextseason: | 2022–23 |
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The 2021–22 season was the first in the history of Macclesfield Football Club. Alongside the North West Counties Premier League, they entered the FA Cup, FA Vase, NWCFL Challenge Cup and the Cheshire Senior Cup. The season covers the period from July 2021 to 30 June 2022.
On 12 March 2022, Macclesfield secured the championship and promotion to the NPL Division One following a 4–0 home win over Ashton Athletic.[1]
Macclesfield's league fixtures for the first half of the season were announced on 2 July 2021.[2] The fixtures for the second half of the season were announced on 28 September 2021.[3]
See main article: 2021–22 FA Cup qualifying rounds. Macclesfield were drawn at home to Burscough in the extra preliminary round and away to Squires Gate in the preliminary round.[4]
See main article: 2021–22 FA Vase. Macclesfield were drawn away to Winterton Rangers in the first qualifying round.[5]
Macclesfield were drawn away to Skelmersdale United in the quarter-final, the match was later switched to the Leasing.com Stadium at Skelmersdale's request.[6]