| Club: | Maccabi Tel Aviv |
| Season: | 2021–22 |
| League: | Premier League |
| League Result: | 3rd |
| Cup1: | State Cup |
| Cup1 Result: | Semi-finals |
| Cup3: | Toto Cup |
| Cup3 Result: | 6th |
| Cup4: | Super Cup |
| Cup4 Result: | 2nd |
| Cup5: | Europa Conference League |
| Cup5 Result: | Knockout round play-offs |
| League Topscorer: | Stipe Perica (15) |
| Season Topscorer: | Stipe Perica (17) |
| Updated: | 22 May 2022 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
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The 2021–22 season is Maccabi Tel Aviv's 115th season since its establishment in 1906 and 74th since the establishment of the State of Israel. During the 2021–22 campaign, the club will compete in the Israeli Premier League, State Cup, Toto Cup, Israeli Super Cup and Europa Conference League.
See main article: 2021–22 Israeli Premier League.
See main article: 2021–22 Israel State Cup.
See main article: 2021–22 Toto Cup Al.
See main article: 2021 Israel Super Cup.
See main article: 2021–22 UEFA Europa Conference League.
See main article: 2021–22 UEFA Europa Conference League qualifying phase and play-off round (Main Path).