| Competition: | Luxembourg National Division |
| Season: | 2021–22 |
| Dates: | 7 August 2021 – 22 May 2022 |
| Winners: | F91 Dudelange |
| Relegated: | RM Hamm Benfica Rodange 91 |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | F91 Dudelange |
| Continentalcup2: | Conference League |
| Continentalcup2 Qualifiers: | Differdange 03 Fola Esch Racing Union |
| League Topscorer: | Dominik Stolz |
| Biggest Home Win: | |
| Biggest Away Win: | |
| Highest Scoring: | |
| Longest Wins: | 7 matches Progrès Niederkorn |
| Longest Unbeaten: | 12 matches Progrès Niederkorn UNA Strassen |
| Longest Winless: | 13 matches RM Hamm Benfica |
| Longest Losses: | 13 matches RM Hamm Benfica |
| Matches: | 240 |
| Total Goals: | 770 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Updated: | 19 March 2022 |
The 2021–22 Luxembourg National Division season is the 108th of top-tier association football in Luxembourg. The season began on 7 August 2021 and ended on 22 May 2022.[1] The league champion will qualify to compete in the 2022–23 UEFA Champions League.[2]
Fola Esch are the defending league champions.[3]
No teams were relegated at the end of the previous season, and no teams were promoted from the Luxembourg Division of Honour.
| Team | Town | Venue | Capacity | |
|---|---|---|---|---|
| Differdange | Stade Municipal Ralf Jänisch | 3,000 | ||
| Ettelbruck | Stade Wëllem Durkheim | 2,020 | ||
| Dudelange | Stade Jos Nosbaum | 2,558 | ||
| Esch-sur-Alzette | Stade Émile Mayrisch | 3,826 | ||
| Hostert | Stade Jos Becker | 1,500 | ||
| Esch-sur-Alzette | Stade Guillaume Schinker | 4,000 | ||
| Mondorf-les-Bains | Stade John Grün | 3,600 | ||
| Niederkorn | Stade Jos Haupert | 2,800 | ||
| Luxembourg City | Stade Achille Hammerel | 5,814 | ||
| Hamm, Luxembourg City | Stade Gauthier Letsch | 2,800 | ||
| Rodange | Stade Joseph Philippart | 3,400 | ||
| Hesperange | Stade Alphonse Theis | 3,058 | ||
| Strassen | Complexe Sportif Jean Wirtz | 2,000[4] | ||
| Pétange | Stade Municipal Jérémy Schulz | 2,400 | ||
| Rosport | Stade Wëllem Hess | 1,000[5] | ||
| Wiltz | Stade Christophe Turpel | 3,000 |
Two play-off matches were played between two teams from the 2021–22 Luxembourg National Division and two teams from the 2021–22 Luxembourg Division of Honour to determine which teams would participate in the 2022–23 Luxembourg National Division.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Dominik Stolz | Swift Hesperange | 19 |
| 2 |  Jordy Soladio | Victoria Rosport | 17 |
| 3 |  Nicolas Perez | UNA Strassen | 15 |
| 4 | Bertino Cabral | Differdange 03 | 13 |
| 5 | Andreas Buch | Differdange 03 | 12 |
 Antonio Luisi | Progrès Niederkorn | ||
| Yann Mabella | Racing FC | ||
| Dejvid Sinani | Differdange 03 | ||
| 9 | Artur Abreu | Union Titus Pétange | 11 |
 Gustavo | Etzella Ettelbruck | ||
| Mayron De Almeida | Progrès Niederkorn |