| Sport: | Women's Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Kansas State Wildcats |
| Conference: | Big 12 Conference |
| Short Conf: | Big 12 |
| Record: | 20–13 |
| Conf Record: | 9–9 |
| Head Coach: | Jeff Mittie |
| Hc Year: | 8th |
| Asst Coach1: | Brian Ostermann |
| Asst Coach2: | Ebony Gilliam |
| Asst Coach3: | Ebony Haliburton |
| Stadium: | Bramlage Coliseum |
| Bowl: | NCAA tournament |
| Bowl Result: | second round |
The 2021–22 Kansas State Wildcats women's basketball team represented Kansas State University in the 2021–22 NCAA Division I women's basketball season. The Wildcats were led by eighth-year head coach Jeff Mittie. They played their home games at Bramlage Coliseum in Manhattan, Kansas and were members of the Big 12 Conference.
On January 23, 2022 against Oklahoma, junior Ayoka Lee set an NCAA women's basketball record of 61 points in a single game, breaking the previous record of 60 points.
They finished the season 9–18, 3–15 in Big 12 play to finish in a tie for ninth place. As the tenth seed in the Big 12 Tournament, they defeated Texas Tech in the First Round before losing to West Virginia in the Quarterfinals. They were not invited to the NCAA tournament or the WNIT.
Source:[1]
|-!colspan=6 style=| Exhibition|-!colspan=6 style=| Non-conference regular season (10–2)|-!colspan=6 style=| Big 12 regular season (9–9)|-!colspan=6 style=| Big 12 Women's Tournament (0–1)|-!colspan=6 style=| NCAA tournament (1–1)
2021–22 NCAA Division I women's basketball rankings
| + Regular Season Polls | Poll | Pre- Season | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | Week 11 | Week 12 | Week 13 | Week 14 | Week 15 | Week 16 | Week 17 | Week 18 | Week 19 | Final |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AP | NR | NR | NR | NR | NR | NR | NR | NR | RV | 25 | RV | 25 | 25 | RV | |||||||
| Coaches | NR | NR | NR | NR | RV | NR | NR | NR | RV | RV | NR | RV | RV | RV |
| Increase in ranking | |||
| Decrease in ranking | |||
| Not ranked previous week | |||
| (RV) | Received Votes |