| Club: | K.V. Oostende |
| Season: | 2021–22 |
| Chairman: | Franck Dierckens |
| Manager: | Yves Vanderhaeghe |
| Stadium: | Diaz Arena |
| League: | Belgian First Division A |
| League Result: | 12th |
| Cup1: | Belgian Cup |
| Cup1 Result: | Seventh round |
| League Topscorer: | Makhtar Gueye (12) |
| Season Topscorer: | Makhtar Gueye (12) |
| Pattern La1: | _kvo2122h |
| Pattern B1: | _kvo2122h |
| Pattern Ra1: | _kvo2122h |
| Leftarm1: | FF0000 |
| Body1: | FF0000 |
| Rightarm1: | FF0000 |
| Shorts1: | 00A553 |
| Socks1: | FF0000 |
| Pattern La2: | _kvo2122a |
| Pattern B2: | _kvo2122a |
| Pattern Ra2: | _kvo2122a |
| Leftarm2: | 231F20 |
| Body2: | 231F20 |
| Rightarm2: | 231F20 |
| Shorts2: | 000000 |
| Socks2: | 000000 |
| Pattern La3: | _kvo2122t |
| Pattern B3: | _kvo2122t |
| Pattern Ra3: | _kvo2122t |
| Leftarm3: | FFFFFF |
| Body3: | FFFFFF |
| Rightarm3: | FFFFFF |
| Shorts3: | FFFFFF |
| Socks3: | FFFFFF |
| Updated: | 10 April 2022 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 118th season in the existence of K.V. Oostende and the club's 10th consecutive season in the top flight of Belgian football. In addition to the domestic league, K.V. Oostende also participated in this season's edition of the Belgian Cup.
See main article: 2021–22 Belgian First Division A.
The league fixtures were announced on 8 June 2021.[1]
See main article: 2021–22 Belgian Cup.