| Mode: | Women's Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | James Madison Dukes |
| Conference: | Colonial Athletic Association |
| Short Conf: | CAA |
| Record: | 14–15 |
| Conf Record: | 10–8 |
| Head Coach: | Sean O'Regan |
| Hc Year: | 6th |
| Asst Coach1: | Ian Caskill |
| Asst Coach2: | Samantha Prahalis-Holmes |
| Asst Coach3: | Kachine Alexander |
| Stadium: | Atlantic Union Bank Center |
The 2021–22 James Madison Dukes women's basketball team represented James Madison University during the 2021–22 NCAA Division I women's basketball season. The Dukes, led by sixth-year head coach Sean O'Regan, played their home games at the Atlantic Union Bank Center as members of the Colonial Athletic Association (CAA). They finished the season 14–15, 10–8 in CAA play. As this was their last season in the CAA, the conference banned all athletic teams at JMU, including women's basketball from participating in all post-season play.
See main article: 2020–21 James Madison Dukes women's basketball team.
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