| Club: | Ismaily SC |
| Season: | 2021–22 |
| Chairman: | Yahya El-Koumi |
| Manager: | Juan Brown (from 13 November) Hamza El-Gamal (from 2 May) |
| Stadium: | Ismailia Stadium |
| League: | Egyptian Premier League |
| League Result: | 11th |
| Cup1: | Egypt Cup |
| Cup1 Result: | Round of 16 |
| Cup2: | EFA Cup |
| Cup2 Result: | Semi-finals |
| League Topscorer: | Mohamed El Shamy (6) |
| Season Topscorer: | Mohamed El Shamy (6) |
| Prevseason: | 2020–21 |
| Nextseason: | 2021–22 |
The 2021–22 Ismaily SC season was the club's 101st season in existence and the 51st consecutive season in the top flight of Egyptian football. In addition to the domestic league, Ismaily participated in this season's editions of the Egypt Cup and the EFA Cup.
| scope=col | Player | Transferred from | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Always Ready | Loan | [1] | ||||||||
| El Sekka El Hadid | [2] | |||||||||
| Ittihad Khanyounis | [3] |
See main article: 2021–22 Egyptian Premier League.
The league fixtures were announced on 12 October 2021.[4]
See main article: 2021–22 Egypt Cup.
See main article: 2022 EFA Cup.