| Conf Record: | 14–4 |
| Bowl: | NCAA tournament |
| Stadium: | Hilton Coliseum |
| Asst Coach3: | Billy Fennelly |
| Asst Coach2: | Latoja Schaben |
| Asst Coach1: | Jodi Steyer |
| Hc Year: | 27th |
| Head Coach: | Bill Fennelly |
| Record: | 28–7 |
| Aprank: | 10 |
| Coachrank: | 8 |
| Short Conf: | Big 12 |
| Conference: | Big 12 Conference |
| Team: | Iowa State Cyclones |
| Next Year: | 2022–23 |
| Prev Year: | 2020–21 |
| Year: | 2021–22 |
| Mode: | Women's Basketball |
| Bowl Result: | Sweet Sixteen |
The 2021–22 Iowa State Cyclones women's basketball team represented Iowa State University during the 2021–22 NCAA Division I women's basketball season. The Cyclones were coached by Bill Fennelly, who was in his 27th season at Iowa State. They played their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference.
The Cyclones finished the 2020–21 season 17–11, 12–6 in Big 12 play to finish in fourth place. The Cyclones fell in the quarterfinals of the Big 12 Tournament to fifth seed Texas. They qualified for the 2021 NCAA tournament as a seven seed, defeating 10 seed Michigan State in the first round before falling to two seed Texas A&M in the second round.
|-!colspan=6 style=| Exhibition|-!colspan=6 style=| Regular Season|-!colspan=6 style=| Big 12 Tournament|-!colspan=6 style=| NCAA Women's Tournament[1]
See main article: 2021–22 NCAA Division I women's basketball rankings.
| AP | 12 | 14 | 13 | 14 | 15 | 12 | 13 | 14 | 12 | 9 | 7 | 13 | 11 | 9 | 6 | 9 | 8 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coaches | 16 | - | 14 | 13 | 16 | 13 | 14 | 14 | 12 | 9 | 7 | 13 | 10 | 9 | 5 | 6 | 7 |
2021–22 Iowa State Cyclones men's basketball team