| Mode: | Women's basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Illinois State Redbirds |
| Conference: | Missouri Valley Conference |
| Record: | 19–14 |
| Conf Record: | 12–6 |
| Head Coach: | Kristen Gillespie |
| Hc Year: | 5th |
| Asst Coach1: | Jessica Keller |
| Ac1 Year: | 5th |
| Asst Coach2: | Scott Gillespie |
| Ac2 Year: | 5th |
| Asst Coach3: | Mariyah Brawner-Henley |
| Ac3 Year: | 4th |
| Stadium: | Redbird Arena |
| Champion: | Missouri Valley Tournament Champions |
| Bowl: | NCAA tournament |
| Bowl Result: | first round |
The 2021–22 Illinois State Redbirds women's basketball team represented Illinois State University during the 2021–22 NCAA Division I women's basketball season. The Redbirds, led by fifth-year head coach Kristen Gillespie, played their home games at the Redbird Arena as members of the Missouri Valley Conference.
They finished the season with a 19–14 overall record, 12–6 in conference play to finish in fourth place. As the fourth seed in the Missouri Valley Tournament, they earned a bye into the Quarterfinals and defeated Loyola–Chicago, Southern Illinois, and Northern Iowa to win the championship. They received an automatic bid to the NCAA tournament, where they were the fifteenth seed in the Greensboro Region. They lost to second seed Iowa in the First Round to end their season.
The Redbirds finished the season with a 16–9 overall record, 12–6 in Missouri Valley play to finish in third place. As the third seed in the Missouri Valley Tournament, they earned a bye into the Quarterfinals where they lost to Loyola–Chicago. They received an at-large bid to the WNIT, where they lost to Tulane in the First Round, defeated Samford in the Consolation Semifinal and lost to UT Martin in the Consolation Final.
Source:[1]
|-!colspan=6 style=| Exhibition|-!colspan=6 style=| Non-Conference Regular season|-!colspan=6 style=| Missouri Valley Regular season|-!colspan=6 style=| Missouri Valley Tournament|-!colspan=6 style=| NCAA tournament
See main article: 2021–22 NCAA Division I women's basketball rankings.
| Increase in ranking | |||
| Decrease in ranking | |||
| Not ranked previous week | |||
| (RV) | Received Votes | ||
| (NR) | Not Ranked and Did not receive votes |
The Coaches Poll did not release a Week 2 poll and the AP Poll did not release a poll after the NCAA Tournament.