| Mode: | Women's Basketball |
| Year: | 2021–2022 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | IUPUI Jaguars |
| Conference: | Horizon League |
| Short Conf: | Horizon |
| Record: | 24–5 |
| Conf Record: | 18–2 |
| Head Coach: | Austin Parkinson |
| Hc Year: | 12th |
| Asst Coach1: | Latrell Flemming |
| Ac1 Year: | 6th |
| Asst Coach2: | Holly Hoopingarner |
| Ac2 Year: | 1st |
| Stadium: | IUPUI Gymnasium |
| Champion: | Horizon League Regular Season Co-Champions Horizon League Tournament Champions |
| Bowl: | NCAA tournament |
| Bowl Result: | first round |
The 2021–22 IUPUI Jaguars women's basketball team represented Indiana University–Purdue University Indianapolis in the 2021–22 NCAA Division I women's basketball season. The Jaguars, led by twelfth-year head coach Austin Parkinson, played their home games at the IUPUI Gymnasium in Indianapolis, Indiana as members of the Horizon League.
They finished the season 24–5 overall and 18–2 in Horizon League play, to finish as co-champions of the regular season. As the first seed in the Horizon League Tournament, they earned a bye into the Quarterfinals where they defeated Robert Morris. They then went on to defeat Oakland in the Semifinals and Cleveland State in the Final to win the championship. As a result, the Jaguars received the conference's automatic bid to the NCAA tournament where they were the thirteenth seed in the Bridgeport Region. This was the first time the team appeared in the NCAA Tournament. They received a bid in 2020, but the tournament was canceled due to the COVID-19 pandemic.[1] They lost in the first round to Oklahoma to end their season.
The Jaguars finished the 2020–21 season 15–5, 11–3 in Horizon League play to finish in fifth place. As the fifth seed in the Horizon League Tournament, they received a bye in to the Quarterfinals where they defeated Oakland. They then defeated Milwaukee in the Semifinals, but fell in the championship to Wright State. They were not invited to the NCAA tournament or the WNIT.
Source:[2]
|-!colspan=6 style=| Exhibition|-!colspan=6 style=| Regular season|-!colspan=6 style=| Horizon League Tournament|-!colspan=6 style=| NCAA tournament|-
See main article: 2021–22 NCAA Division I women's basketball rankings.
| Increase in ranking | |||
| Decrease in ranking | |||
| Not ranked previous week | |||
| (RV) | Received Votes | ||
| (NR) | Not Ranked and Did not receive votes |
The Coaches Poll did not release a Week 2 poll and the AP Poll did not release a poll after the NCAA Tournament.