| Mode: | Basketball |
| Year: | 2021–22 |
| Team: | Holy Cross Crusaders |
| Conference: | Patriot League |
| Short Conf: | Patriot |
| Record: | 9–22 |
| Conf Record: | 7–11 |
| Head Coach: | Brett Nelson |
| Hc Year: | 3rd |
| Asst Coach1: | R.J. Evans |
| Asst Coach2: | Sam Ferry |
| Asst Coach3: | Joe Kennedy |
| Stadium: | Hart Center |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
The 2021–22 Holy Cross Crusaders men's basketball team represented the College of the Holy Cross in the 2021–22 NCAA Division I men's basketball season. The Crusaders, led by third-year head coach Brett Nelson, played their home games at the Hart Center in Worcester, Massachusetts as members of the Patriot League.
In a season limited due to the ongoing COVID-19 pandemic, the Crusaders finished the 2020–21 season 5–11 in Patriot League play before suspending their season after positive COVID-19 tests within the program. They did not participate in the Patriot League tournament.
[2] |-!colspan=9 style=|Non-conference regular season
|-!colspan=9 style=|Patriot League regular season|-!colspan=9 style=|Patriot League Tournament|-