| Mode: | Basketball |
| Year: | 2021–22 |
| Team: | Hampton Pirates |
| Conference: | Big South Conference |
| Short Conf: | Big South |
| Record: | 9–19 |
| Conf Record: | 5–11 |
| Hc Year: | 13th |
| Assoc Coach: | Darryl Sharp |
| Asst Coach1: | Matthew Hamilton |
| Asst Coach2: | Keith Coutreyer |
The 2021–22 Hampton Pirates men's basketball team represented Hampton University in the 2021–22 NCAA Division I men's basketball season. The Pirates, led by 13th-year head coach Edward Joyner Jr., played their home games at the Hampton Convocation Center in Hampton, Virginia as members of the Big South Conference. They finished the season 9–19, 5–11 in Big South play, to finish in last place in the North Division. As the No. 10 seed in the Big South tournament, they lost to High Point in the first round.[1]
The season marked the school's last season as a member of the Big South as the Pirates joined the Colonial Athletic Association in 2022.
In a season limited due to the ongoing COVID-19 pandemic, the Pirates finished the 2020–21 season 11–14, 9–9 in Big South play, to finish in seventh place. They lost to Radford in the quarterfinals of the Big South tournament.[2]
|-!colspan=12 style=| Non-conference regular season|-!colspan=12 style=| Big South Conference regular season|-!colspan=12 style=| Big South tournament|-|-Source:[3]