| Competition: | Guadeloupe Division of Honor |
| Season: | 2021–22 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Guadeloupe Division of Honor season is the 71st season of the league. The defending champions, AS Gosier, are vying in Group B for their 3rd title and their 3rd consecutive one.