| Mode: | Women's basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Grand Canyon Antelopes |
| Conference: | Western Athletic Conference |
| Short Conf: | WAC |
| Record: | 22–9 |
| Conf Record: | 14–4 |
| Hc Year: | 2nd |
| Asst Coach1: | Nia Jackson |
| Asst Coach2: | Buck Scheel |
| Asst Coach3: | Greg Gottlieb |
The 2021–22 Grand Canyon Antelopes women's basketball team represents Grand Canyon University in Phoenix, Arizona, during the 2021–22 NCAA Division I women's basketball season. The Antelopes, led by second year head coach Molly Miller, play their home games at the GCU Arena as members of the Western Athletic Conference.
[1] [2] |-!colspan=12 style=| Exhibition|-!colspan=12 style=| Non-conference regular season|-!colspan=12 style=| WAC conference season|-!colspan=9 style=|WAC Tournament|-!colspan=9 style=|WNIT