| Club: | Genoa |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Enrico Preziosi Alberto Zangrillo |
| Mgrtitle: | Head coach |
| Manager: | Davide Ballardini (until 6 November 2021) Andriy Shevchenko (from 7 November 2021 to 15 January 2022) Abdoulay Konko (caretaker, from 15 January 2022 to 19 January 2022) Alexander Blessin (from 19 January 2022) |
| Stadium: | Stadio Luigi Ferraris |
| League: | Serie A |
| League Result: | 19th (relegated) |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Mattia Destro (9) |
| Season Topscorer: | Mattia Destro (9) |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 129th season in the existence of Genoa C.F.C. and the club's 15th consecutive season in the top flight of Italian football. In addition to the domestic league, Genoa participated in this season's edition of the Coppa Italia.
| scope=col | Player | Transferred from | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 3 | Internazionale | Loan | [2] | |||||||
| 57 | Torino | Free | [3] | |||||||
| 20 | Trabzonspor | Undisclosed | [4] [5] | |||||||
| 1 | Chievo | Free | [6] | |||||||
| 36 | Young Boys | €5M | [7] | |||||||
| 55 | Brighton & Hove Albion | Loan | [8] | |||||||
| 45 | Sturm Graz | €6.5M | [9] | |||||||
| 16 | Roma | Loan | [10] | |||||||
| 9 | Atalanta | Loan | [11] | |||||||
| 8 | Bayer Leverkusen | Loan | [12] | |||||||
| 11 | AZ | Undisclosed | [13] |
| scope=col | Player | Transferred to | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 14 | Roma | €17.5M | [14] | |||||||
| 2 | Brescia | Loan | [15] | |||||||
| 14 | Fatih Karagümrük | Loan | [16] | |||||||
| 66 | Benevento | Loan | [17] | |||||||
| 8 | Parma | Loan | [18] | |||||||
| 94 | Fatih Karagümrük | Loan | [19] | |||||||
| 24 | Brescia | Loan | [20] | |||||||
| 9 | Internazionale | Loan | [21] | |||||||
| 11 | Brescia | Free | [22] | |||||||
| 19 | Parma | Undisclosed | [23] | |||||||
| 21 | Salernitana | Free | [24] |
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[25]
See main article: 2021–22 Coppa Italia.
|-! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers|-! colspan=14 style=background:#dcdcdc; text-align:center| Defenders|-! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders|-! colspan=14 style=background:#dcdcdc; text-align:center| Forwards|-! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season