| Club: | Galatasaray Nef |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Burak Elmas |
| Mgrtitle: | Head coach |
| Manager: | Ekrem Memnun (until 18 March 2022) Andreas Pistiolis (from 19 March 2022) |
| Stadium: | Sinan Erdem Dome |
| League Result: | 3rd seed |
| Playoffs Result: | Semifinals |
| League2: | Basketball Champions League |
| League2 Result: | Round of 16 |
| Cup1: | Turkish Basketball Cup |
| Cup1 Result: | Semifinals |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season is Galatasaray's 110th season in the existence of the club. The team plays in the Basketball Super League and in the Basketball Champions League.
It has been announced that as of 18 March 2022, the paths parted with Ekrem Memnun, who has been working as the head coach of the Galatasaray Men's Basketball Team since January 2020-21 season.[1]
As of 19 March 2022, Galatasaray Nef appointed Andreas Pistiolis, who was the first assistant coach in the CSKA Moscow technical staff, to the head coach.[2]
DeVaughn Akoon-Purcell, who had ruptured Achilles tendon in the Riesen Ludwigsburg match played on 23 March 2022, closed the season.[3]
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See main article: 2021–22 Basketbol Süper Ligi.
Note: All times are TRT (UTC+3) as listed by the Turkish Basketball Federation.
See main article: 2021–22 Basketball Champions League.
See main article: 2022 Turkish Basketball Cup.